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History
Zolpidem was developed in the late 1980s and approved by the U.S. Food and Drug Administration (FDA) in 1992. It was introduced as an alternative sleep medication with fewer risks of dependence and side effects compared to traditional benzodiazepines.
Effects of Zolpidem
Zolpidem works by binding to GABA receptors in the brain, specifically to the omega-1 subtype of the benzodiazepine receptor. This increases the activity of GABA, an inhibitory neurotransmitter, leading to a sedative effect and inducing sleep. The effect usually begins within 15-30 minutes after ingestion and lasts for about 6-8 hours.
Comparison of Zolpidem with other benzodiazepines
Unlike benzodiazepines, Zolpidem has a more selective action on GABA receptors, resulting in less muscle relaxation and anticonvulsant effects. This makes Zolpidem specifically effective for promoting sleep without the broad spectrum effects of benzodiazepines. Moreover, Zolpidem has a shorter half-life, which reduces the risk of sleepiness the next day compared to long-acting benzodiazepines such as diazepam.
Interactions
Zolpidem may interact with other drugs that suppress the central nervous system, such as alcohol, opioids and other sedatives. It may also interact with drugs that inhibit or induce CYP3A4 enzymes, which may affect the breakdown of Zolpidem. It is important to inform your doctor about all medicines you are taking to avoid possible interactions.
Positive effects of Zolpidem
- Effective short-term treatment of insomnia
- Rapid onset of sleep
- Reduction of night waking
- Improving sleep quality
- Lower risk of dependence compared to benzodiazepines
Side effects of Zolpidem
- Dizziness
- Daytime sleepiness
- Headache
- Nausea
- Memory problems
- Abnormal behaviors or thoughts (such as sleepwalking)
- Allergic reactions such as rashes, itching or swelling
Medical advice
Zolpidem should be used strictly as directed by a physician. It is intended for short-term use, usually no longer than a few weeks, to reduce the risks of dependence and tolerance. It is important not to drink alcohol or use other sedatives during treatment with Zolpidem. Side effects such as daytime sleepiness or behavioral changes should be reported to a doctor immediately. Always consult a doctor before starting or stopping the use of Zolpidem, and discuss any underlying health problems and other medications you are taking.